

Audited annual filings, TTM ratios and consensus forward estimates
Wall Street price targets and rating actions
Revenue disaggregation per 10-K filing
Annual filings (FY) with consensus forward estimates (hatched)
1255 daily bars · split adjusted
Current price $45.15
Latest analyst grade actions
| Date | Firm | Action | Previous | New grade |
|---|---|---|---|---|
| Sep 24, 26 |
Daily · Wilder smoothing
| Citizens |
| maintain |
| Market Outperform |
| Market Outperform |
| Aug 17, 26 | Guggenheim | maintain | Buy | Buy |
| Aug 13, 26 | Citizens | maintain | Market Outperform | Market Outperform |
| Jun 1, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| May 14, 26 | Citizens | maintain | Market Outperform | Market Outperform |
| Mar 10, 26 | Citizens | maintain | Market Outperform | Market Outperform |
| Mar 10, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Feb 19, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Dec 3, 25 | Leerink Partners | upgrade | Market Perform | Outperform |
Classic floor pivots from 2026-10-23
Computed from daily OHLCV bars
| Indicator | Value | Type | Action |
|---|---|---|---|
| RSI (14) | 49.19 | Oscillator | Neutral |
| Stochastic %K (14, 3, 3) | 73.67 | Oscillator | Neutral |
| Williams %R (14) | -18.13 | Oscillator | Sell |
| MACD (12, 26, 9) | -1.99 (Hist 0.62) | Oscillator | Buy |
| Average Directional Index (14) | 30.79 (+DI 18.0 / -DI 19.5) | Trend | Strong Sell |
| EMA 20 | 44.46 | MA | Buy |
| SMA 20 | 43.74 | MA | Strong Buy |
| EMA 50 | 47.63 | MA | Strong Sell |
| SMA 50 | 50.68 | MA | Strong Sell |
| SMA 200 | 56.59 | MA | Strong Sell |
TTM vs. 5-year historical average (annual ratios)
| Metric | SPRB | Historical (5Y) / ref | Status |
|---|---|---|---|
| P/E ratio (TTM) | -1.1x | -2.1x · sector 20.7x | Discount |
| Forward P/E (FY26E) | -1.8x | EPS est. -25.74 | Elevated |
| Price / Book | 1.3x | 1.2x | In line |
| Price / Sales | — | 2.9x | Discount |
| EV / EBITDA | -0.8x | -1.0x | Discount |
| Return on equity | -123.5% | — | Weak |
| Gross margin | 0.0% | 40.0% | Below hist. |
| Debt / Equity | 0.09 | 0.06 | Conservative |
| Piotroski / Altman Z | 2/9 | Z -0.79 | Distress |
Discounted cash flow model
Stock news · updated daily
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will participate in a fireside chat at the Craig-Hallum Biotech Catalyst Conference on October 22, 2026. An archived copy of the webcast will be available on the events sec.
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that data from Study 250-902 (NCT03227042), a prospective, multicenter, multinational, noninterventional, longitudinal natural history study designed to characterize disease progression in pediatric participants with severe, non-attenua.
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at the H.C. Wainwright 28th Annual Global Investment Conference on September 15, 2026, at 2:00 p.m. ET in New York.Interested parties can access the live webcas.
Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disor
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the launch of MPS3BStudy.com, a dedicated online resource for families and caregivers of children with Sanfilippo Syndrome Type B (MPS IIIB). The website enables families and caregivers to learn about, and register their interest in, t.
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB) (“Spruce”), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that it has completed two pre-BLA meetings with the U.S. Food and Drug Administration (FDA) that support the company's plan to submit a BLA for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanf.
Spruce Biosciences, Inc. (Nasdaq: SPRB) a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disord
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today reported financial results for the second quarter ended June 30, 2026, and provided corporate updates. “The second quarter was a period of significant execution as we advanced TA-ERT toward our planned BLA submission in the fourth quarter, which.
Reported EPS vs. consensus estimate
| Report date | EPS est. | EPS actual | Surprise | Revenue |
|---|---|---|---|---|
| Aug 12, 2026 | -5.79 | -6.68 | Miss -15.4% | — |
| May 13, 2026 | -7.32 | -8.94 | Miss -22.1% | — |
| Mar 9, 2026 | -12.87 | -9.58 | Beat 25.6% | — |
| Nov 10, 2025 | -15.56 | -14.58 | Beat 6.3% | — |
| Aug 15, 2025 | -18.00 | -3.50 | Beat 80.6% | — |
| May 6, 2025 | -18.80 | -24.00 | Miss -27.7% | — |
Free float vs. closely held shares
13F institutional holdings are not available in the current data plan.
SEC Form 4 filings
| Date | Insider | Role | Type | Shares @ price | Value |
|---|---|---|---|---|---|
| Jul 27, 26 | Quartel Adrian W | officer: Chief Medical Officer | A-Award | 13,000 | — |
| 10-Q | Aug 12, 2026 | 2026-08-12 09:10:42 | View |
| 8-K | Aug 12, 2026 | 2026-08-12 09:05:17 | View |
| SC 13G/A | Aug 4, 2026 | 2026-08-04 19:51:19 | View |
| SC 13G | Jul 30, 2026 | 2026-07-30 11:18:27 | View |
| 4 | Jul 29, 2026 | 2026-07-29 16:10:50 | View |
| 3 | Jul 29, 2026 | 2026-07-29 16:09:05 | View |
Proxy statement (DEF 14A) disclosures
| Jul 27, 26 |
| Quartel Adrian W |
| 0 |
| — |
| Jun 30, 26 | Szwarcberg Javier B. | director, officer: CHIEF EXECUTIVE OFFICER | A-Award | 266 @ $4.53 | $1.21K |
| May 21, 26 | Spiegelman Daniel K | director | A-Award | 1,700 @ $52.70 | $89.59K |
| May 21, 26 | Simpson Camilla V | director | A-Award | 1,700 @ $52.70 | $89.59K |
| May 21, 26 | Grey Michael G | director, officer: Executive Chairman | A-Award | 1,700 @ $52.70 | $89.59K |
| May 21, 26 | Barretto-Ko Percival | director | A-Award | 1,700 @ $52.70 | $89.59K |
| May 21, 26 | Walbert Keli | director | A-Award | 1,700 @ $52.70 | $89.59K |