

Audited annual filings, TTM ratios and consensus forward estimates
Wall Street price targets and rating actions
Revenue disaggregation per 10-K filing
Annual filings (FY) with consensus forward estimates (hatched)
1255 daily bars · split adjusted
Daily · Wilder smoothing
Classic floor pivots from 2026-10-23
Computed from daily OHLCV bars
| Indicator | Value | Type | Action |
|---|---|---|---|
| RSI (14) | 39.83 | Oscillator | Neutral |
| Stochastic %K (14, 3, 3) | 44.11 | Oscillator | Neutral |
| Williams %R (14) | -76.90 | Oscillator | Neutral |
| MACD (12, 26, 9) | -1.58 (Hist 0.47) | Oscillator | Buy |
| Average Directional Index (14) | 34.62 (+DI 16.3 / -DI 28.8) | Trend | Strong Sell |
| EMA 20 | 44.73 | MA | Strong Sell |
| SMA 20 | 44.03 | MA | Sell |
| EMA 50 | 49.28 | MA | Strong Sell |
| SMA 50 | 50.52 | MA | Strong Sell |
| SMA 200 | 67.69 | MA | Strong Sell |
Current price $42.93
Latest analyst grade actions
| Date | Firm | Action | Previous | New grade |
|---|---|---|---|---|
| Oct 22, 26 | BMO Capital | upgrade | Market Perform | Outperform |
| Oct 15, 26 | UBS | upgrade | Neutral | Buy |
| Sep 24, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Sep 22, 26 | JP Morgan | maintain | Overweight | Overweight |
| Sep 15, 26 | Guggenheim | maintain | Buy | Buy |
| Sep 9, 26 | Barclays | maintain | Overweight | Overweight |
| Sep 8, 26 | Canaccord Genuity | maintain | Buy | Buy |
| Sep 8, 26 | Morgan Stanley | maintain | Overweight | Overweight |
| Sep 8, 26 | Goldman Sachs | maintain | Neutral | Neutral |
TTM vs. 5-year historical average (annual ratios)
| Metric | IONS | Historical (5Y) / ref | Status |
|---|---|---|---|
| P/E ratio (TTM) | -12.4x | -47.3x · sector 20.7x | Discount |
| Forward P/E (FY26E) | -12.0x | EPS est. -3.58 | In line |
| Price / Book | 16.1x | 13.7x | Elevated |
| Price / Sales | 8.2x | 8.9x | In line |
| EV / EBITDA | -19.2x | -206.9x | Discount |
| Return on equity | -110.8% | — | Weak |
| Gross margin | 98.2% | 98.4% | In line |
| Debt / Equity | 5.50 | 3.10 | Levered |
| Piotroski / Altman Z | 2/9 | Z 1.00 | Distress |
Discounted cash flow model
FY2025 · 10-K disclosure
SEC EDGAR filings · last 12 months
| Form | Filed | Accepted | Document |
|---|---|---|---|
| 8-K | Oct 23, 2026 | 2026-10-23 13:41:58 | View |
| 8-K | Oct 21, 2026 | 2026-10-21 16:15:17 | View |
| 4 | Oct 19, 2026 | 2026-10-19 21:40:12 | View |
| 4 | Oct 19, 2026 | 2026-10-19 21:40:02 | View |
| 8-K | Sep 23, 2026 | 2026-09-23 06:03:20 | View |
| 8-K | Sep 4, 2026 | 2026-09-04 17:00:39 | View |
| 8-K | Sep 4, 2026 | 2026-09-04 06:01:59 | View |
| 4 | Sep 2, 2026 | 2026-09-02 20:32:51 | View |
| 4 | Sep 2, 2026 | 2026-09-02 20:22:31 | View |
| 4 | Sep 2, 2026 | 2026-09-02 20:22:24 | View |
Proxy statement (DEF 14A) disclosures
Free float vs. closely held shares
13F institutional holdings are not available in the current data plan.
SEC Form 4 filings
| Date | Insider | Role | Type | Shares @ price | Value |
|---|---|---|---|---|---|
| Oct 15, 26 | Devers Shannon L. | officer: EVP, Chief Human Resources Ofc | M-Exempt | 2,820 | — |
| Oct 15, 26 | Devers Shannon L. | officer: EVP, Chief Human Resources Ofc | M-Exempt | 2,820 | — |
| Oct 16, 26 | Devers Shannon L. | officer: EVP, Chief Human Resources Ofc | S-Sale | 1,357 @ $43.54 | $59.08K |
| Oct 15, 26 | Swayze Eric | officer: EVP Research | M-Exempt | 125 | — |
| Oct 15, 26 | Swayze Eric | officer: EVP Research | M-Exempt | 125 | — |
| Oct 16, 26 | Swayze Eric | officer: EVP Research | S-Sale | 53 @ $43.54 | $2.31K |
| Aug 31, 26 | Bennett C Frank | officer: EVP, Chief Scientific Officer | J-Other | 110 @ $51.31 | $5.64K |
| Aug 31, 26 | O'Neil Patrick R. | officer: EVP CLO & General Counsel | J-Other | 63 @ $51.31 | $3.23K |
Stock news · updated daily
CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner Roche announced today late-breaking oral presentation data from the ongoing Phase 3 IMAgINATION study in adults with primary IgA nephropathy (IgAN) receiving optimized standard of care, demonstrating that investigational sefaxersen achieved a statistically significant and clinically meaningful 43.1% reduction in proteinuria (95% confidence interval [CI]: 32.5 - 52.0, P
[url="]Ionis Pharmaceuticals, Inc.[/url] (Nasdaq: IONS) today announced that the company was named the top employer to work for by Science in its annual Top Emp
CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the company was named the top employer to work for by Science in its annual Top Employers survey of the biotech and pharmaceutical industries. Rising from #2 last year to #1, Ionis was recognized for its industry-leading innovation, talented employees and strong values-based culture.“Being recognized as the #1 top employer by Science in only our second year of eligibility is a testament to the extr.
[url="]Ionis Pharmaceuticals, Inc.[/url] (Nasdaq: IONS) partner GSK today announced that the U.S. Food and Drug Administration (FDA) has approved Hibsago(bepiro
CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner GSK today announced that the U.S. Food and Drug Administration (FDA) has approved Hibsago (bepirovirsen) for the treatment of chronic hepatitis B (CHB) virus infection in combination with nucleos(t)ide analogue reverse transcriptase inhibitor (NrtI) therapy in adult patients without cirrhosis, receiving NrtI therapy for at least 6 months, who have suppressed HBV deoxyribonucleic acid (DNA), and with hepatitis.
Ionis Pharmaceuticals, Inc. (NASDAQ: IONS - Get Free Report) EVP Shannon Devers sold 1,357 shares of the stock in a transaction on Friday, October 16th. The stock was sold at an average price of $43.54, for a total value of $59,083.78. Following the completion of the transaction, the executive vice president directly owned 17,811 shares of
CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the indication extension for TRYNGOLZA® (olezarsen) as an adjunct to diet, in combination with other lipid-lowering therapies, for the treatment of adult patients with severe hypertriglyceridemia (sHTG, fasting triglyceride levels of ≥880 mg/dL [≥10 mmol/L]).
Alnylam cut its full-year revenue guidance due to slower-than-expected sales for Amvuttra. Ionis experienced two pipeline setbacks on the same day in July.
Reported EPS vs. consensus estimate
| Report date | EPS est. | EPS actual | Surprise | Revenue |
|---|---|---|---|---|
| Jul 29, 2026 | -1.09 | -0.69 | Beat 36.7% | $268.0M |
| Apr 29, 2026 | -0.85 | -0.56 | Beat 34.1% | $246.0M |
| Feb 25, 2026 | -1.24 | -1.41 | Miss -14.0% | $203.0M |
| Oct 29, 2025 | -1.15 | -0.61 | Beat 47.0% | $156.7M |
| Jul 30, 2025 | 0.27 | 0.86 | Beat 218.5% | $452.0M |
| Apr 30, 2025 | -1.11 | -0.75 | Beat 32.4% | $131.6M |