

Audited annual filings, TTM ratios and consensus forward estimates
Wall Street price targets and rating actions
Revenue disaggregation per 10-K filing
Annual filings (FY) with consensus forward estimates (hatched)
1254 daily bars · split adjusted
Current price $0.5177
Latest analyst grade actions
| Date | Firm | Action | Previous | New grade |
|---|---|---|---|---|
| Aug 13, 26 | Wedbush | maintain | Outperform | Outperform |
| May 14, 26 | Wedbush | maintain | Outperform | Outperform |
| Mar 31, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Mar 31, 26 | Wedbush | maintain | Outperform | Outperform |
| Feb 10, 26 | Wedbush | maintain | Outperform | Outperform |
| Jan 29, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Dec 18, 25 | HC Wainwright & Co. |
Daily · Wilder smoothing
| maintain |
| Buy |
| Buy |
| Jan 15, 25 | HC Wainwright & Co. | maintain | Buy | Buy |
| Dec 17, 24 | HC Wainwright & Co. | maintain | Buy | Buy |
Classic floor pivots from 2026-10-23
Computed from daily OHLCV bars
| Indicator | Value | Type | Action |
|---|---|---|---|
| RSI (14) | 32.36 | Oscillator | Neutral |
| Stochastic %K (14, 3, 3) | 17.04 | Oscillator | Buy |
| Williams %R (14) | -87.73 | Oscillator | Buy |
| MACD (12, 26, 9) | -0.05 (Hist -0.01) | Oscillator | Strong Sell |
| Average Directional Index (14) | 17.43 (+DI 17.4 / -DI 21.5) | Trend | Neutral |
| EMA 20 | 0.61 | MA | Strong Sell |
| SMA 20 | 0.62 | MA | Strong Sell |
| EMA 50 | 0.67 | MA | Strong Sell |
| SMA 50 | 0.71 | MA | Strong Sell |
| SMA 200 | 0.76 | MA | Strong Sell |
Free float vs. closely held shares
13F institutional holdings are not available in the current data plan.
SEC Form 4 filings
| Date | Insider | Role | Type | Shares @ price | Value |
|---|---|---|---|---|---|
| Jun 16, 26 | Grissinger Michael | director | A-Award | 12,555 @ $0.7293 | $9.16K |
| Jun 16, 26 | Grissinger Michael | director | A-Award | 3,135 | — |
| Jun 16, 26 | Gruia Gabriela | director | A-Award | 12,555 @ $0.7293 | $9.16K |
| Jun 16, 26 | Gruia Gabriela | director | A-Award | 3,135 | — |
| Jun 16, 26 | Peters Richard | director | A-Award | 12,555 @ $0.7293 | $9.16K |
| Jun 16, 26 | Peters Richard | director | A-Award | 3,135 | — |
| Jun 16, 26 | Henneman John B Iii | director | A-Award | 3,135 | — |
| Jun 16, 26 | Henneman John B Iii | director | A-Award | 12,555 @ $0.7293 | $9.16K |
TTM vs. 5-year historical average (annual ratios)
| Metric | APRE | Historical (5Y) / ref | Status |
|---|---|---|---|
| P/E ratio (TTM) | -0.5x | -0.9x · sector 20.7x | Discount |
| Forward P/E (FY26E) | -1.6x | EPS est. -0.32 | Elevated |
| Price / Book | 0.7x | 0.7x | In line |
| Price / Sales | — | 8.2x | Discount |
| EV / EBITDA | 2.8x | 0.4x | Elevated |
| Return on equity | -46.7% | — | Weak |
| Gross margin | 0.0% | -84.9% | Below hist. |
| Debt / Equity | 0.00 | 0.00 | Conservative |
| Piotroski / Altman Z | 3/9 | Z -10.11 | Distress |
Discounted cash flow model
SEC EDGAR filings · last 12 months
| Form | Filed | Accepted | Document |
|---|---|---|---|
| 8-K | Aug 28, 2026 | 2026-08-28 08:30:17 | View |
| SC 13G/A | Aug 13, 2026 | 2026-08-13 14:27:09 | View |
| 10-Q | Aug 12, 2026 | 2026-08-12 08:40:46 | View |
| 8-K | Aug 12, 2026 | 2026-08-12 08:35:13 | View |
| 8-K | Jul 23, 2026 | 2026-07-23 16:05:20 | View |
| 4 | Jun 17, 2026 | 2026-06-17 19:09:50 | View |
| 4 | Jun 17, 2026 | 2026-06-17 19:08:24 | View |
| 4 | Jun 17, 2026 | 2026-06-17 19:06:45 | View |
| 4 | Jun 17, 2026 | 2026-06-17 19:05:47 | View |
| 4 | Jun 17, 2026 | 2026-06-17 19:04:37 | View |
Proxy statement (DEF 14A) disclosures
Stock news · updated daily
DOYLESTOWN, Pa., Oct. 16, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced that it will host a virtual panel discussion, "The State of WEE1 Inhibition in Precision Oncology," on Tuesday, October 20, 2026, at 11 am ET.
Company to participate in 2026 Maxim Growth Summit (October 14) and Regional Biotechnology Conference (October 15) Company to participate in 2026 Maxim Growth Summit (October 14) and Regional Biotechnology Conference (October 15)
DOYLESTOWN, Pa., Sept. 22, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced that an abstract featuring updated interim results from the ongoing Phase 1 ACESOT-1051 study of its WEE1 inhibitor APR-1051 in patients with advanced solid tumors has been accepted for oral presentation at the 38th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (ENA 2026), to take place November 18-20, 2026, in Barcelona, Spain.
DOYLESTOWN, Pa., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced that Oren Gilad, Ph.D., President and Chief Executive Officer, will present at the H.C. Wainwright 28th Annual Global Investment Conference, to be held in person and virtually September 14-16, 2026.
Company Strengthens Global Intellectual Property Portfolio with 28 Issued and 30 Pending Patents Company Strengthens Global Intellectual Property Portfolio with 28 Issued and 30 Pending Patents
Enrollment in the ongoing Phase 1 dose escalation ACESOT-1051 trial of oral WEE1 inhibitor APR-1051 is accelerating as dose escalation advances
SALT LAKE CITY, Aug. 3, 2026 /PRNewswire/ -- Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company leveraging its proprietary technology platform to augment therapeutics through effective oral delivery, today announced the appointment of Michael J. Grissinger to its Board of Directors, effective August 3, 2026.
Next clinical data update from the ongoing Phase 1 dose escalation ACESOT-1051 trial anticipated at a medical meeting in Q4 2026, providing a near-term opportunity to demonstrate continued clinical progress with APR-1051 Enrollment in ACESOT-1051 is accelerating as the Company advances dose escalation and amasses the clinical data needed to inform dose selection and subsequent development Aprea plans to advance APR-1051 in uterine serous carcinoma (USC) and Cyclin E–overexpressing platinum-resistant ovarian cancer (PROC) while also evaluating combination regimens with standard of care in HPV-positive head and neck cancer and colorectal cancer, utilizing dose levels that have shown single-agent activity and cleared safety review The expanded development strategy builds on emerging single-agent activity and positions APR-1051 across biomarker-defined indications where WEE1 inhibition may address significant unmet medical need DOYLESTOWN, Pa., July 30, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today provided an update on the ongoing Phase 1 dose escalation ACESOT-1051 trial of its oral WEE1 inhibitor APR-1051.
Reported EPS vs. consensus estimate
| Report date | EPS est. | EPS actual | Surprise | Revenue |
|---|---|---|---|---|
| Aug 12, 2026 | -0.18 | -0.07 | Beat 60.6% | — |
| May 13, 2026 | -0.23 | -0.22 | Beat 4.3% | $140.5K |
| Mar 16, 2026 | -0.38 | -0.32 | Beat 15.8% | $3.34K |
| Nov 12, 2025 | -0.11 | -0.47 | Miss -327.3% | $1.85K |
| Aug 12, 2025 | -0.77 | -0.53 | Beat 31.2% | $118.1K |
| May 14, 2025 | -0.65 | -0.66 | Miss -0.9% | $162.5K |