

Audited annual filings, TTM ratios and consensus forward estimates
Wall Street price targets and rating actions
Revenue disaggregation per 10-K filing
Annual filings (FY) with consensus forward estimates (hatched)
Free float vs. closely held shares
13F institutional holdings are not available in the current data plan.
SEC Form 4 filings
| Date | Insider | Role | Type | Shares @ price | Value |
|---|---|---|---|---|---|
| Oct 2, 26 | Supran Bryan | officer: EVP, CLO and Secretary | S-Sale | 1,758 @ $226.88 | $398.9K |
| Sep 19, 26 | Greenstreet Yvonne | director, officer: Chief Executive Officer | A-Award | 107 | — |
| Jun 1, 26 | Pyott David E I | director | M-Exempt | 3,830 | — |
| Jun 1, 26 | Pyott David E I | director | S-Sale | 921 @ $297.71 | $274.2K |
| Jun 1, 26 | Pyott David E I | director | S-Sale | 1,175 @ $298.91 | $351.2K |
| Jun 1, 26 | Pyott David E I | director | S-Sale | 1,222 @ $299.87 | $366.4K |
| Jun 1, 26 | Pyott David E I | director | S-Sale | 495 @ $300.72 | $148.9K |
| Jun 1, 26 | Pyott David E I | director | S-Sale | 17 @ $302.65 | $5.15K |
FY2025 · 10-K disclosure
FY2025 · 10-K disclosure
Stock news · updated daily
[url="]Alnylam Pharmaceuticals, Inc.[/url] (Nasdaq: ALNY), the leading RNAi therapeutics company, today reported positive initial Phase 1b clinical trial result
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today reported positive initial Phase 1b clinical trial results for ALN-HTT02, an investigational RNAi therapeutic in development for the treatment of Huntington's disease, which will be developed under the International Nonproprietary Name (INN) brezosiran (bre-ZOH-sir-an). The data were presented in oral and poster presentations at the European Huntington's Disease Network (.
Alnylam (ALNY) possesses the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.
Alnylam's stock has plunged more than 40% this year, but the company's financials look great. Investors have been spooked by a guidance cut and a rival drug's clinical setback.
Curated Wealth Partners LLC decreased its stake in shares of Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) by 96.9% in the undefined quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission. The institutional investor owned 1,095 shares of the biopharmaceutical company's stock after selling 34,533 shares during the period.
First Citizens Bank and Trust Co. bought a new position in Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) during the undefined quarter, according to its most recent disclosure with the Securities and Exchange Commission. The firm bought 2,874 shares of the biopharmaceutical company's stock, valued at approximately $709,000. Several other hedge funds have also recently
[url="]Alnylam Pharmaceuticals, Inc.[/url] (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today that it will report financial results for the
Alnylam cut its full-year revenue guidance due to slower-than-expected sales for Amvuttra. Ionis experienced two pipeline setbacks on the same day in July.
Reported EPS vs. consensus estimate
| Report date | EPS est. | EPS actual | Surprise | Revenue |
|---|---|---|---|---|
| Jul 30, 2026 | 1.63 | 1.21 | Miss -25.8% | $1.29B |
| Apr 30, 2026 | 0.87 | 1.51 | Beat 73.2% | $1.17B |
| Feb 12, 2026 | 1.16 | 0.82 | Miss -29.3% | $1.10B |
| Oct 30, 2025 | 0.56 | 1.84 | Beat 228.0% | $1.25B |
| Jul 31, 2025 | -0.54 | -0.51 | Beat 6.2% | $773.7M |
| May 1, 2025 | -0.89 | -0.44 | Beat 50.6% | $594.2M |
Current price $233.29
Latest analyst grade actions
| Date | Firm | Action | Previous | New grade |
|---|---|---|---|---|
| Oct 14, 26 | Wells Fargo | maintain | Equal Weight | Equal Weight |
| Oct 14, 26 | Citigroup | maintain | Buy | Buy |
| Oct 8, 26 | RBC Capital | maintain | Outperform | Outperform |
| Sep 30, 26 | JP Morgan | maintain | Overweight | Overweight |
| Sep 21, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Sep 8, 26 | Jefferies | maintain | Hold | Hold |
| Sep 2, 26 | HC Wainwright & Co. | maintain | Buy | Buy |
| Aug 19, 26 | BMO Capital | maintain | Outperform | Outperform |
| Aug 14, 26 | Wells Fargo | maintain | Equal Weight | Equal Weight |
1255 daily bars · split adjusted
TTM vs. 5-year historical average (annual ratios)
| Metric | ALNY | Historical (5Y) / ref | Status |
|---|---|---|---|
| P/E ratio (TTM) | 38.2x | -9.0x · sector 20.7x | Elevated |
| Forward P/E (FY26E) | 35.1x | EPS est. 6.65 | In line |
| Price / Book | 23.0x | 51.4x | Discount |
| Price / Sales | 6.5x | 18.4x | Discount |
| EV / EBITDA | 26.7x | -48.9x | Discount |
| Return on equity | 93.6% | — | Top tier |
| Gross margin | 79.7% | 83.5% | In line |
| Debt / Equity | 0.94 | 1.67 | Moderate |
| Piotroski / Altman Z | 6/9 | Z 5.02 | Safe zone |
Discounted cash flow model
Daily · Wilder smoothing
Classic floor pivots from 2026-10-19
Computed from daily OHLCV bars
| Indicator | Value | Type | Action |
|---|---|---|---|
| RSI (14) | 48.06 | Oscillator | Neutral |
| Stochastic %K (14, 3, 3) | 43.10 | Oscillator | Neutral |
| Williams %R (14) | -54.26 | Oscillator | Neutral |
| MACD (12, 26, 9) | -4.20 (Hist 0.49) | Oscillator | Buy |
| Average Directional Index (14) | 13.68 (+DI 21.6 / -DI 21.9) | Trend | Neutral |
| EMA 20 | 233.65 | MA | Sell |
| SMA 20 | 235.53 | MA | Sell |
| EMA 50 | 242.15 | MA | Strong Sell |
| SMA 50 | 238.70 | MA | Sell |
| SMA 200 | 293.48 | MA | Strong Sell |
SEC EDGAR filings · last 12 months
| Form | Filed | Accepted | Document |
|---|---|---|---|
| 4 | Oct 6, 2026 | 2026-10-06 16:12:25 | View |
| 4 | Sep 22, 2026 | 2026-09-22 16:07:02 | View |
| 10-Q | Jul 30, 2026 | 2026-07-30 08:11:02 | View |
| 8-K | Jul 30, 2026 | 2026-07-30 08:06:25 | View |
| 4 | Jun 3, 2026 | 2026-06-03 20:25:20 | View |
| 4 | Jun 3, 2026 | 2026-06-03 20:23:40 | View |
| 3 | Jun 3, 2026 | 2026-06-03 16:21:30 | View |
| 144 | Jun 1, 2026 | 2026-06-01 20:25:14 | View |
| 8-K | May 27, 2026 | 2026-05-27 16:30:22 | View |
| 4 | May 22, 2026 | 2026-05-22 16:20:46 | View |
Proxy statement (DEF 14A) disclosures